Fulvestrant and breast cancer cells
Image by Kenneth Nephew
The figures show that fulvestrant-mediated cytoplasmic localization of ER is associated with intermediate filament proteins CK8 and CK18. After treatment of MCF-7 and T47D cells (breast cancer cells) with Fulvestrant, dramatic cytoplasmic localization of ER was observed. The results indicate that the presence of CK8 and CK18 is necessary for fulvestrant-induced cytoplasmic localization of ER, which keeps the receptor away from the nucleus where it could activate growth promoting genes.2009Image by Kenneth NephewFulvestrant and breast cancer cells
Copyright Holder: Image by Kenneth Nephew
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