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Chemical Biology

IU chemists' work will aid drug design to target cancer and inflammatory disease

folate receptor

Chemists at Indiana University Bloomington have produced detailed descriptions of the structure and molecular properties of human folate receptor proteins, a key development for designing new drugs that can target cancer and inflammatory diseases without serious side effects.   Full Story >>

Targeted peptide-estrogen combination found effective and safe for treating obesity in mice

Richard DiMarchi

Scientists at Indiana University and international collaborators have found a way to link two hormones into a single molecule, producing a more effective therapy with fewer side effects for potential use as treatment for obesity and related medical conditions. The studies were carried out in the laboratories of IU chemist Richard DiMarchi and Matthias Tschöp in Munich, Germany.   Full Story >>

Filming bacterial life in multicolor as a new diagnostic and antibiotic discovery tool

Amino Acids

An international team of scientists led by Indiana University chemist Michael S. VanNieuwenhze and biologist Yves Brun has discovered a revolutionary new method for coloring the cell wall of bacterial cells to determine how they grow, in turn providing a new, much-needed tool for the development of new antibiotics.   Full Story >>

IU chemists Carlson, Skrabalak named Cottrell Scholars

Erin Carlson and Sara Skrabalak

Erin E. Carlson and Sara E. Skrabalak, assistant professors of chemistry at IU Bloomington, are among the 11 recipients in 2012 of Cottrell Scholar awards, a highly selective program that recognizes early-career researchers and promotes outstanding teaching. Carlson also has been awarded a 2012 National Science Foundation Faculty CAREER Award, the foundation's most prestigious award in support of junior faculty.   Full Story >>

Indiana University chemist Carlson receives NIH Director’s New Innovator award

Erin Carlson

Erin E. Carlson, an assistant professor of chemistry at Indiana University Bloomington, has been awarded a National Institutes of Health Director's New Innovator Award, intended to stimulate innovative research and support promising new scientists. The award will provide $1.5 million over five years to support Carlson's research, which deals with developing improved treatments for drug-resistant infections.   Full Story >>

IU Bloomington to receive $1.2 million for Huntington's disease research

Ybe photo

The National Institutes of Health has approved a $1.2 million, four-year grant that will allow Indiana University Bloomington scientists to continue their study of Huntington's disease. The project, led by IU Bloomington structural biologist Joel Ybe, has focused on the interaction of two proteins, HIP1 (Huntingtin-interacting protein 1) and HIPPI (HIP1-protein interactor), whose association is believed to trigger the death of nervous system cells.   Full Story >>