Scientists at Work: Center for Genomics and Bioinformatics

Center for Genomics and Bioinformatics robot The Center for Genomics and Bioinformatics at Indiana University Bloomington turns 10 this year. CGB is somewhat more precocious than your average fifth-grader, however. While other 10-year-olds are learning about integers and African nations this fall, CGB will be busy mapping whole-organism genomes and bringing millions of dollars in research money to the state of Indiana. CGB was by the Office of the Vice President for Research and the College of Arts and Sciences with seed funding from the Indiana Genomics Initiative, or INGEN. IUB biologist Peter Cherbas is its first director. CGB staff are currently working on 60 projects with collaborators from IU and other institutions. The center occupies several thousand square feet in Jordan, Myers, and Simon halls and has grown from a handful of staff to 52 full- and part-time employees.  Full Story

IU physicist's idea puts women in control at CERN

ATLAS Gagnon

Thanks to a successful proposal made by Indiana University senior research scientist Pauline Gagnon, the European Organization for Nuclear Research (CERN) on March 8 marked International Women's Day by staffing all control rooms of the world's largest physics laboratory with women. In addition to originating the idea, Gagnon, a senior research scientist in the IU College of Arts and Sciences' Department of Physics, also coordinated the effort that will mean the accelerators and detectors of the biggest physics lab in the world will all be run primarily by women.

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Breast cancer drug fulvestrant appears more effective in the presence of CK8 and CK18

Fulvestrant and breast cancer cells

Women's responsiveness to the second-line breast cancer drug fulvestrant may depend on whether the cancer cells are expressing two key proteins, Indiana University Bloomington scientists report in this month's Cancer Biology & Therapy. Fulvestrant appeared to exert maximum anti-cancer effects in vitro when cells produced normal or elevated quantities of the cytokeratins CK8 and CK18, structural proteins that help give the nucleus its shape.

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IU trustees approve design of new science and engineering lab at IUPUI

Fountain photo

The Indiana University Board of Trustees have approved the construction of a new Science and Engineering Laboratory Building on the Indiana University-Purdue University Indianapolis campus. The Science and Engineering Laboratory Building at IUPUI is the first step in an effort to meet the space needs of the Schools of Science (SOS) and Engineering and Technology (E&T).

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IU research team discovers TB disease mechanism and molecule to block it

Medical Science image

Indiana University School of Medicine researchers have identified a mechanism used by the tuberculosis bacterium to evade the body's immune system and have identified a compound that blocks the bacterium's ability to survive in the host, which could lead to new drugs to treat tuberculosis. Zhong-Yin Zhang, Robert A. Harris Professor and chairman of the Department of Biochemistry and Molecular Biology, and his colleagues revealed the biochemical processes that TB bacteria employ to subvert macrophages - key infection-fighting cells - in a recent early edition of the Proceedings of the National Academy of Sciences. They also described a compound they have synthesized - I-A09 - that blocked the TB bacterium's activity in laboratory tests.

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Biologist Yves Brun elected a fellow of the American Academy of Microbiology

Yves Brun

Yves Brun, an Indiana University Bloomington microbiologist who has brought multidisciplinary rigor to the study of bacteria, has been elected a Fellow of the American Academy of Microbiology. It is a major honor in Brun's field. Brun is invited to attend a special event at the American Society of Microbiology's annual meeting in San Diego. The American Academy of Microbiology is a division of the Society.

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More alcohol sales sites mean more neighborhood violence, new Indiana University research finds


More alcohol sales sites in a neighborhood equate to more violence, and the highest assault rates are associated with carry-out sites selling alcohol for off-premise consumption, according to new research released Feb. 21 by two Indiana University Bloomington professors. Using crime statistics and alcohol outlet licensing data from Cincinnati to examine the spatial relationship between alcohol outlet density and assault density, Department of Criminal Justice professor William Alex Pridemore and Department of Geography professor Tony Grubesic found that off-premise outlets appeared to be responsible for about one in four simple assaults and one in three aggravated assaults.

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Previous issue

Edenberg photo

The Feb. 16, 2009, issue of Discoveries featured IU School of Medicine geneticist Howard Edenberg and his interdisciplinary research on alcohol, alcohol metabolism, and alcoholism. Also featured were stories about wasp parasites, new teaching labs at IU Bloomington, a new agreement for the IU Research & Technology Corporation, enzymes and heart attacks, field opportunities for IPFW anthropology students, and the coming of Captain Kidd's "Great" cannon.

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