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Tiny Worlds Microscopy

A dividing Potoroo (rat kangaroo) kidney cell. The mitotic spindle is shown in green and the chromosomes in purple.

In the center is a two cell embryo of a small nematode (worm). The chromosomes are seen in red and the poles that will set-up the mitotic spindle are seen in green.

This is an interphase kidney cell from a Potoroo (rat kangaroo). In red is the DNA in the cell nucleus, in green are the fibers called microtubules that are part of the cell skeleton.

A mouse inhibitory neuron (green) from the hippocampus, a region associated with memory formation. The red staining is a protein implicated in inflammation and yellow indicates regions of overlap.

Oocytes from 2 different species of fruit fly.DNA is shown in blue and points of DNA replication in red. The results from this study provided insights into the evolution of DNA replication control in these flies, and have implications for understandingcancer in humans.

The Down Syndrome Critical Region1 protein (in red) is in mouse hippocampal neurons (in blue). This image is part of a study of the underlying mechanisms of mental retardation in Down syndrome.

A virus protein (green) can penetrate into Barley leaf cells with high efficiency. This work can help to better understand how virus infects plants and provide valuable information for anti-virus research.

A culture of mammalian cells. In red is a protein from the bacteria that causes the plague. This work will help to understand what happens in infected cells and possibly lead to new treatments.

Sperm from a New Zealand Snail species. Size and structure of sperm are measured to determinedifferences between snail populations.

Microscopic root hairs of the plant Arabidopsis thaliana, common name thale cress. Arabidopsis is a common weed found all over the world and is used to study plant genetics, development and cell biology.

Outer surface of a thale cress leaf. Structures that look like mouths are called stomata. Stomata help

the plant breathe. Unlike humans, plants inhale carbon dioxide and exhale oxygen.

Arabidopsis seedling. Young plants must find light in order to live. They search for light by growing at an incredibly fast rate. Arabidopsis seedlings can grow 500 times larger within a few days.

Leaf cells in the plant thale cress. The puzzle-piece shape of leaf cells is thought to hold the leaf together in high winds. The yellow fibers are important for forming the jig-saw shape.

Fibers in Arabidopsis leaf cells. It has been known for decades that these fibers control plant growth. Some herbicides work by destroying these fibers, leading to plant death.

Plant cell membranes involved in nutrient recycling (small green specks).Understanding how this recycling system is regulated is providing new insights intothe immune system (red structures are chloroplasts).

A mitotic spindle in a dividing rat kangaroo kidney epithelial cell.Microtubules are in orange, DNA in blue. These are good cells for imaging mitosis because they are flat and have a small number of chromosomes.

Mitotic spindle in a rat kangaroo kidney cell. A protein known to be involved in spindle assembly has been depleted to determine its function. Spindle in orange, DNA in blue, DNA-to-spindle attachment site in green.

A montage of spindle and chromosomal movement defects in human retinal cells depleted for a protein involved in attaching chromosomes to the spindle. Spindle (red), DNA (blue), DNA-to-spindle attachment site in green.

A mitotic human bone cancer cell. Three proteins necessary for cell division are labeled. Unregulated cell division is a hallmark of cancer and mitotic proteins are a primary target of chemotherapy treatments.

Slide show created by Chris Meyer and David Bricker, University

Communications, with invaluable assistance from IU LMIC Executive

Director Claire Walczak and Manager James Powers.

The IU Light Microscopy Imaging Center is supported with grants from the

IU Office of the Vice President for Research, the IU College of Arts and

Sciences, the Indiana METACyt Initiative, and the National Institutes of


Scientific research using LMIC images is supported by the National

Institutes of Health, the National Science Foundation, and the American

Cancer Society, among others.

For more information about the LMIC, please visit the link below: